Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CDD-2807
Catalog No.: PC-22383Not For Human Use, Lab Use Only.
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.
CDD-2807 displays >9-fold selective STK33 inhibitor versus other kinases, including CLK1/2/4 and RET.
CDD-2807 treatment (50 mg/kg/day) induces a reversible contraceptive effect in mice, could easily cross the blood-testis barrier to cause infertility.
CDD-2807 is an excellent chemical probe that can be used to perform additional safety and toxicological studies in vivo, including analysis in nonhuman primates.
| M.Wt | 446.55 | |
| Formula | C29H26N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Ku AF, et al. Science. 2024 May 24;384(6698):885-890.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
