Chemical Structure : CDD-2807
CAS No.:
CDD-2807
(CDD2807)
Catalog No.: PC-22383Not For Human Use, Lab Use Only.
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.
CDD-2807 displays >9-fold selective STK33 inhibitor versus other kinases, including CLK1/2/4 and RET.
CDD-2807 treatment (50 mg/kg/day) induces a reversible contraceptive effect in mice, could easily cross the blood-testis barrier to cause infertility.
CDD-2807 is an excellent chemical probe that can be used to perform additional safety and toxicological studies in vivo, including analysis in nonhuman primates.
Physicochemical Properties
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M.Wt
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446.55
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Formula
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C29H26N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3-([1,1'-biphenyl]-2-ylethynyl)-1H-indazol-5-yl)(2,6-diazaspiro[3.5]nonan-2-yl)methanone
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References
1. Ku AF, et al. Science. 2024 May 24;384(6698):885-890.
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