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Chemical Structure : CDD-2807
Catalog No.: PC-22383Not For Human Use, Lab Use Only.
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.
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CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.
CDD-2807 displays >9-fold selective STK33 inhibitor versus other kinases, including CLK1/2/4 and RET.
CDD-2807 treatment (50 mg/kg/day) induces a reversible contraceptive effect in mice, could easily cross the blood-testis barrier to cause infertility.
CDD-2807 is an excellent chemical probe that can be used to perform additional safety and toxicological studies in vivo, including analysis in nonhuman primates.
| M.Wt | 446.55 | |
| Formula | C29H26N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ku AF, et al. Science. 2024 May 24;384(6698):885-890.
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