CDDO-TFEA | Nrf2 activator | Probechem Biochemicals

Chemical Structure : CDDO-TFEA

CAS No.: 932730-52-4

CDDO-TFEA (CDDO-Trifluoethyl amide, RTA 404, TP-500)

Catalog No.: PC-25215Not For Human Use, Lab Use Only.

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5 mg	$288	In stock
10 mg	$478	In stock
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Biological Activity

CDDO-TFEA (RTA 404, TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier, an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells.
CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging from 85-170 nM.
CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease.

Physicochemical Properties

M.Wt	572.71
Formula	C33H43F3N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-N-(2,2,2-trifluoroethyl)-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxamide

References

1. Stack, et al. Free Radic. Biol. Med. 49(2), 147-158 (2010).

2. Borbala Daroczi, et al. Mol Cancer Ther. 2009 Sep;8(9):2625-34.

CDDO-TFEA (CDDO-Trifluoethyl amide, RTA 404, TP-500)

Biological Activity

Physicochemical Properties

References

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