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Chemical Structure : CDK2 inhibitor 5
Catalog No.: PC-20887Not For Human Use, Lab Use Only.
CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1.
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CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1.
CDK2 inhibitor 5 demonstrates negative cooperativity with cyclin A.
CDK2 inhibitor 5 is selective for CDK2 over the very similar CDK1 in this cellular context.
CDK2 inhibitor 5 does not show >80% inhibition of any kinase at a 10 µM concentration, and only 4% of the 371 kinases tested showed >50% inhibition.
CDK2 inhibitor 5 recapitulates features of Cdk2−/− and Spdya−/− phenotypes in spermatocytes.
| M.Wt | 427.22 | |
| Formula | C18H14BrF3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Erik B Faber, et al. Nat Commun. 2023 Jun 3;14(1):3213.
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