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CDK2 inhibitor 5

Chemical Structure : CDK2 inhibitor 5

CAS No.: 2891574-96-0

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CDK2 inhibitor 5

Catalog No.: PC-20887Not For Human Use, Lab Use Only.

CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1.
CDK2 inhibitor 5 demonstrates negative cooperativity with cyclin A.
CDK2 inhibitor 5 is selective for CDK2 over the very similar CDK1 in this cellular context.
CDK2 inhibitor 5 does not show >80% inhibition of any kinase at a 10 µM concentration, and only 4% of the 371 kinases tested showed >50% inhibition.
CDK2 inhibitor 5 recapitulates features of Cdk2−/− and Spdya−/− phenotypes in spermatocytes.

Physicochemical Properties

M.Wt 427.22
Formula C18H14BrF3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)C1=CC(C(F)(F)F)=CC=C1NCCC2=CNC3=C2C=CC(Br)=C3

References

1. Erik B Faber, et al. Nat Commun. 2023 Jun 3;14(1):3213.

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