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CDK9-IN-4d

Chemical Structure : CDK9-IN-4d

CAS No.: 2105956-51-0

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CDK9-IN-4d

Catalog No.: PC-62848Not For Human Use, Lab Use Only.

CDK9-IN-4d is a highly potent, selective CDK9 inhibitor with IC50 of 12 nM, shows good selectivity in CDKs kinase profiling assay against CDK kinases and cell proliferation inhibition.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CDK9-IN-4d is a highly potent, selective CDK9 inhibitor with IC50 of 12 nM, shows good selectivity in CDKs kinase profiling assay against CDK kinases and cell proliferation inhibition.
    CDK9-IN-4d blocks the cell cycle both in G0/G1 and G2/M phase to prevent the proliferation and differentiation of cancer cells.
    CDK9-IN-4d significantly suppresses cancer with low toxicity in mice bared-breast cancer.

    Physicochemical Properties

    M.Wt 569.641
    Formula C31H32FN7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

    References

    1. Li Y, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3231-3237.

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