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CDK9 inhibitor VC-1

Chemical Structure : CDK9 inhibitor VC-1

CAS No.:

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CDK9 inhibitor VC-1 (VC-1, VCC972839:01)

Catalog No.: PC-22380Not For Human Use, Lab Use Only.

CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.
VC-1 reduces MCL-1 and cFLIP anti-apoptotic proteins and killed cells, almost exclusively, by intrinsic apoptosis.
VC-1does not synergise with chemotherapy, but dispalys high efficacy in chemotherapy-resistant cells.
VC-1 effectively reduced tumour growth and improved survival in both autochthonous and syngeneic SCLC models.

Physicochemical Properties

M.Wt 408.47
Formula C24H20N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)phenyl)-4-(2-methoxyphenyl)-1,3,5-triazin-2-amine

References

1. Valdez Capuccino L, et al. Cell Death Dis. 2024 May 20;15(5):345.

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