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Chemical Structure : CDK9 inhibitor VC-1
Catalog No.: PC-22380Not For Human Use, Lab Use Only.
CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.
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CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.
VC-1 reduces MCL-1 and cFLIP anti-apoptotic proteins and killed cells, almost exclusively, by intrinsic apoptosis.
VC-1does not synergise with chemotherapy, but dispalys high efficacy in chemotherapy-resistant cells.
VC-1 effectively reduced tumour growth and improved survival in both autochthonous and syngeneic SCLC models.
| M.Wt | 408.47 | |
| Formula | C24H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Valdez Capuccino L, et al. Cell Death Dis. 2024 May 20;15(5):345.
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