Chemical Structure : CDKL2 inhibitor 9
CAS No.:
2471972-15-1
CDKL2 inhibitor 9
Catalog No.: PC-22396Not For Human Use, Lab Use Only.
CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays.
CDKL2 inhibitor 9 exhibits IC50 of 460 nM in the CDKL2 NanoBRET assay to gauge their ability to engage CDKL2 in cells.
CDKL2 inhibitor 9 displays excellent kinome-wide selectivity against 403 wild-type human kinases with selectivity score (S10(1 µM) = 0.002), as well as high selectivity over CDKL1, CDKL3, CDKL4, or CDKL5.
CDKL2 inhibitor 9 suppressed the CDKL2-mediated EB2 phosphorylation in a dose-dependent manner in rat primary neurons.
Physicochemical Properties
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M.Wt
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426.54
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Formula
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C22H26N4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(6-(3-(((2-methylpropyl)sulfonamido)methyl)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
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References
1. Bashore FM, et al. bioRxiv [Preprint]. 2024 May 14:2024.05.12.593776.
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