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Chemical Structure : CDKL2 inhibitor 9
Catalog No.: PC-22396Not For Human Use, Lab Use Only.
CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays.
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CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays.
CDKL2 inhibitor 9 exhibits IC50 of 460 nM in the CDKL2 NanoBRET assay to gauge their ability to engage CDKL2 in cells.
CDKL2 inhibitor 9 displays excellent kinome-wide selectivity against 403 wild-type human kinases with selectivity score (S10(1 µM) = 0.002), as well as high selectivity over CDKL1, CDKL3, CDKL4, or CDKL5.
CDKL2 inhibitor 9 suppressed the CDKL2-mediated EB2 phosphorylation in a dose-dependent manner in rat primary neurons.
| M.Wt | 426.54 | |
| Formula | C22H26N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bashore FM, et al. bioRxiv [Preprint]. 2024 May 14:2024.05.12.593776.
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