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Chemical Structure : CDK inhibitor 24
Catalog No.: PC-49076Not For Human Use, Lab Use Only.
CDK inhibitor 24 is a potent inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 4/20/64 nM for CDK2/9/12, respectively.
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CDK inhibitor 24 is a potent inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 4/20/64 nM for CDK2/9/12, respectively.
CDK inhibitor 24 causes dephosphorylation of retinoblastoma protein and RNA polymerase II, leading to induction of apoptosis in cellular assays in lymphoma cell lines.
CDK inhibitor 24 also induces proteasome-dependent degradation of cyclin K both in vitro and in a patient-derived xenograft in vivo.
CDK inhibitor 24 has a dual mechanism of action, acting as a CDK inhibitor and as a molecular glue inducing an interaction between CDK12 and DDB1 that leads to polyubiquitination of cyclin K and its subsequent degradation.
| M.Wt | 420.539 | |
| Formula | C21H24N8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Radek Jorda, et al. J. Med. Chem. 2022.
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