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Chemical Structure : CE-224535
Catalog No.: PC-61575Not For Human Use, Lab Use Only.
CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP).
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CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP).
CE-224535 demonstrates potential antiinflammatory action in various conditions such as arthritis, allergies, asthma, COPD, autoimmune diseases and other disorders.
| M.Wt | 480.946 | |
| Formula | C22H29ClN4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Duplantier AJ, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11.
2. Stock TC, et al. J Rheumatol. 2012 Apr;39(4):720-7.
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