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CE-224535

Chemical Structure : CE-224535

CAS No.: 724424-43-5

CE-224535 (CE224535, PF-04905428)

Catalog No.: PC-61575Not For Human Use, Lab Use Only.

CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP).
CE-224535 demonstrates potential antiinflammatory action in various conditions such as arthritis, allergies, asthma, COPD, autoimmune diseases and other disorders.

Physicochemical Properties

M.Wt 480.946
Formula C22H29ClN4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Chloro-N-[(1-hydroxycycloheptyl)methyl]-5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]benzamide

References

1. Duplantier AJ, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11.

2. Stock TC, et al. J Rheumatol. 2012 Apr;39(4):720-7.

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