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CE3F4

Chemical Structure : CE3F4

CAS No.: 143703-25-7

CE3F4 (EPAC1 inhibitor CE3F4)

Catalog No.: PC-63111Not For Human Use, Lab Use Only.

CE3F4 is a potent, noncompetitive EPAC1 inhibitor that blocks EPAC1-induced Rap1 activation both in cell-free systems and in intact cells and did not influence protein kinase A holoenzyme activity.

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Biological Activity

CE3F4 is a potent, noncompetitive EPAC1 inhibitor that blocks EPAC1-induced Rap1 activation both in cell-free systems and in intact cells and did not influence protein kinase A holoenzyme activity.
CE3F4 reduces the exchange activity of Epac1 induced by 007 (2 uM) with IC50 of 23 uM.
CE3F4 is a useful pharmacological tools for determining the biological functions of EPAC1 in a wide range of biological processes.

Physicochemical Properties

M.Wt 351.01
Formula C11H10Br2FNO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde

References

1. Courilleau D, et al. J Biol Chem. 2012 Dec 28;287(53):44192-202.

2. Courilleau D, et al. Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8.

3. Brown LM, et al. J Biol Chem. 2014 Mar 21;289(12):8217-30.

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