CEP-11981 (ESK981) | VEGFR/TIE-2/FGFR1 inhibitor

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Chemical Structure : CEP-11981

CAS No.: 856691-93-5

CEP-11981 (ESK981, CEP 11981, CEP11981)

Catalog No.: PC-70185Not For Human Use, Lab Use Only.

CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM.

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10 mg	$588	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM.
CEP-11981 demonstrates a significant pre-clinical activity against human urothelial carcinoma (UC) xenografts.

Physicochemical Properties

M.Wt	477.56
Formula	C28H27N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	13-isobutyl-4-methyl-10-(pyrimidin-2-ylamino)-1,2,4,7,8,13-hexahydro-6H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-6-one

References

1. Hudkins RL, et al. J Med Chem. 2012 Jan 26;55(2):903-13.

2. Jian W, et al. Anticancer Res. 2014 Jul;34(7):3377-82.

3. Levitt JM, et al. J Clin Oncol. 2013 Feb 20;31(6_suppl):293.

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CEP-11981 (ESK981, CEP 11981, CEP11981)

Biological Activity

Physicochemical Properties

References

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