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CEP-11981

Chemical Structure : CEP-11981

CAS No.: 856691-93-5

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CEP-11981 (ESK981, CEP 11981, CEP11981)

Catalog No.: PC-70185Not For Human Use, Lab Use Only.

CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM.
    CEP-11981 demonstrates a significant pre-clinical activity against human urothelial carcinoma (UC) xenografts.

    Physicochemical Properties

    M.Wt 477.56
    Formula C28H27N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    13-isobutyl-4-methyl-10-(pyrimidin-2-ylamino)-1,2,4,7,8,13-hexahydro-6H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-6-one

    References

    1. Hudkins RL, et al. J Med Chem. 2012 Jan 26;55(2):903-13.

    2. Jian W, et al. Anticancer Res. 2014 Jul;34(7):3377-82.

    3. Levitt JM, et al. J Clin Oncol. 2013 Feb 20;31(6_suppl):293.

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