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Chemical Structure : CEP-33779
CAS No.: 1257704-57-6
Catalog No.: PC-21900Not For Human Use, Lab Use Only.
CEP-33779 is a potent, selective, and orally bioavailable inhibitor of JAK2 with IC50 of 1.3 nM, 65-fold selective over JAK-3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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CEP-33779 is a potent, selective, and orally bioavailable inhibitor of JAK2 with IC50 of 1.3 nM, 65-fold selective over JAK-3.
CEP-33779 decreases NF-κB activation modulating the proinflammatory tumor microenvironment.
CEP-33779 impacts neoplasia by restricting tumor cell proliferation and angiogenesis.
CEP-33779 strongly suppresses growth of established tumors in an AOM/DSS–induced model of colorectal cancer.
CEP-33779 mitigates several immune parameters associated with SLE advancement, including the protection and treatment of mice with lupus nephritis.
| M.Wt | 462.57 | |
| Formula | C24H26N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(3-(4-Methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine |
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1. Seavey MM, et al. Mol Cancer Ther. 2012 Apr;11(4):984-93.
2. Lu LD, et al. J Immunol. 2011 Oct 1;187(7):3840-53.
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