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CFI-401870

Chemical Structure : CFI-401870

CAS No.: 1599460-95-3

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CFI-401870 (CFI401870;CFI 401870)

Catalog No.: PC-60266Not For Human Use, Lab Use Only.

CFI-401870 is a potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CFI-401870 is a potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM.
    CFI-401870 displays low off-target activity (>500-fold) and microsomal stability.
    CFI-401870 inhibits HCT116 cell growth with GI50 of <0.1 uM, demonstrates in vivo tumor growth inhibition.

    Physicochemical Properties

    M.Wt 493.611
    Formula C30H31N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((R)-cyclopropyl(pyridin-2-yl)methyl)-3-(4-((1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide

    References

    1. Liu Y, et al. J Med Chem. 2015 Apr 23;58(8):3366-92.

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