Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Monopolar Spindle 1 (Mps1/TTK)-CFI-401980
CFI-401980

Chemical Structure : CFI-401980

CAS No.: 1610676-27-1

Add to Favorites

CFI-401980 (CFI401980)

Catalog No.: PC-62727Not For Human Use, Lab Use Only.

CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase, MPS1) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
200 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase, MPS1) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM.
    CFI-401980 shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%).

    Physicochemical Properties

    M.Wt 498.587
    Formula C28H30N6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-cyclopropyl-2-methyl-4-(2-phenoxy-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide

    References

    1. Laufer R, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: