Chemical Structure : CFI-402257
CAS No.: 1610759-22-2
Catalog No.: PC-42354Not For Human Use, Lab Use Only.
A potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM; exhibit effects consistent with Mps1 kinase inhibition, specifically SAC inactivation, leading to chromosome missegregation, aneuploidy, and ultimately cell death; well-tolerated in mouse models of human cancer and orally active.
M.Wt | 498.58 | |
Formula | C28H30N6O3 | |
CAS No. | 1610759-22-2 | |
Storage |
|
|
Solubility |
DMSO: 10 mM (Need Warming and Ultrasonic) |
|
Chemical Name |
Benzamide, N-cyclopropyl-4-[7-[[(cis-3-hydroxy-3-methylcyclobutyl)methyl]amino]-5-(3-pyridinyloxy)pyrazolo[1,5-a]pyrimidin-3-yl]-2-methyl- |
1. Mason JM, et al. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132.
2. Liu Y, et al. ACS Med Chem Lett. 2016 May 6;7(7):671-5.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright