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Chemical Structure : CFI-402257
CAS No.: 1610759-22-2
Catalog No.: PC-42354Not For Human Use, Lab Use Only.
CFI-402257 (CFI 402257) is a potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $438 | In stock | |
| 25 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CFI-402257 (CFI 402257) is a potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM.
CFI-402257 exhibits effects consistent with Mps1 kinase inhibition, specifically SAC inactivation, leading to chromosome missegregation, aneuploidy, and ultimately cell death.
CFI-402257 is well-tolerated in mouse models of human cancer and orally active.
| M.Wt | 498.58 | |
| Formula | C28H30N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM (Need Warming and Ultrasonic) |
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| Chemical Name/SMILES |
Benzamide, N-cyclopropyl-4-[7-[[(cis-3-hydroxy-3-methylcyclobutyl)methyl]amino]-5-(3-pyridinyloxy)pyrazolo[1,5-a]pyrimidin-3-yl]-2-methyl- |
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1. Mason JM, et al. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132.
2. Liu Y, et al. ACS Med Chem Lett. 2016 May 6;7(7):671-5.
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