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Chemical Structure : CGP-74514A hydrochloride
Catalog No.: PC-62821Not For Human Use, Lab Use Only.
CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM.
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CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM.
CGP-74514A induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.
CGP-74514A increases p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2).
| M.Wt | 422.35 | |
| Formula | C19H24ClN7 · HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dai Y, et al. Cell Cycle. 2002 Mar-Apr;1(2):143-52.
2. Yu C, et al. Cancer Res. 2003 Apr 15;63(8):1822-33.
3. Dai X, et al. Cell Cycle. 2012 Aug 15;11(16):3079-86.
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