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CGS 21680

Chemical Structure : CGS 21680

CAS No.: 120225-54-9

CGS 21680 (CGS-21680;CGS21680)

Catalog No.: PC-43385Not For Human Use, Lab Use Only.

CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM.
CGS 21680 significantly upregulates CD39 and CD73 expression, accelerates the ATP hydrolysis and adenosine generation.
CGS 21680 reduces the number of infiltrated granulocytes into the ischemic tissue in rat model of transient cerebral ischemia.

Physicochemical Properties

M.Wt 499.5197
Formula C23H29N7O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzenepropanoic acid, 4-[2-[[6-amino-9-(N-ethyl-.beta.-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]-

References

1. Nekooeian AA, et al. Br J Pharmacol. 1998 Apr;123(8):1666-72.

2. Phillis JW, et al. Brain Res. 1990 Feb 19;509(2):328-30.

3. Komaki S, et al. Neurosci Lett. 2012 Jul 26;522(1):21-4.

4. Melani A, et al. Brain Res. 2014 Mar 10;1551:59-72.

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