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CGS 21680 hydrochloride

Chemical Structure : CGS 21680 hydrochloride

CAS No.: 124431-80-7

CGS 21680 hydrochloride (CGS-21680 Hydrochloride;CGS21680 Hydrochloride)

Catalog No.: PC-43386Not For Human Use, Lab Use Only.

CGS 21680 hydrochloride is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CGS 21680 hydrochloride is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM.
CGS 21680 significantly upregulates CD39 and CD73 expression, accelerates the ATP hydrolysis and adenosine generation.
CGS 21680 reduces the number of infiltrated granulocytes into the ischemic tissue in rat model of transient cerebral ischemia.

Physicochemical Properties

M.Wt 535.9806
Formula C23H30ClN7O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 20 mg/mL

Chemical Name/SMILES

3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid hydrochloride

References

1. Nekooeian AA, et al. Br J Pharmacol. 1998 Apr;123(8):1666-72.

2. Phillis JW, et al. Brain Res. 1990 Feb 19;509(2):328-30.

3. Komaki S, et al. Neurosci Lett. 2012 Jul 26;522(1):21-4.

4. Melani A, et al. Brain Res. 2014 Mar 10;1551:59-72.

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