Chemical Structure : CH-126
CAS No.:
862975-78-8
CH-126
(CH126)
Catalog No.: PC-28696Not For Human Use, Lab Use Only.
CH-126 is a specific small molecule inhibitor of CHOP/ATF4 (activating transcription factor 4/ C/EBP homologous protein) expression, inhibits ER stress-induced CHOP expression with IC50 of 2 uM in Tm&Tg induced-CHOP-Luc cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CH-126 is a specific small molecule inhibitor of CHOP/ATF4 (activating transcription factor 4/ C/EBP homologous protein) expression, inhibits ER stress-induced CHOP expression with IC50 of 2 uM in Tm&Tg induced-CHOP-Luc cells.
CH-126 does not affect the immediate upstream regulators of CHOP/ATF4, phosphorylation of PERK or eIF2α, and does not modulate ER stress in general as it does not affect the levels of IRE1α, XBP-1 splicing (XBP-1s), or ATF6.
CH-126 inhibits neuronal ER stress and provide significant neuroprotection of RGC somata and axons in the traumatic ON crush (ONC) model.
CH-126 promotes significant survival of RGCs somata and axons and preserve visual function in the mouse silicone oil-induced ocular hypertension glaucoma model.
Physicochemical Properties
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M.Wt
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371.43
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Formula
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C17H13N3O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 2-((6-methoxybenzo[d]thiazol-2-yl)amino)benzo[d]thiazole-6-carboxylate
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References
1. Li M, et al. Cell Rep. 2026 Oct 27;45(11):118225.
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