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CH24H inhibitor 17

Chemical Structure : CH24H inhibitor 17

CAS No.: 1613480-70-8

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CH24H inhibitor 17

Catalog No.: PC-38337Not For Human Use, Lab Use Only.

CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.
CH24H inhibitor 17 shows excellent selectivity for CYP3A4 as well as CYP2C8, CYP2C9, and CYP2D6 (IC50>10 uM).
CH24H inhibitor 17 reduces 24S-hydroxycholesterol levels in the mouse brain when oral administration treatment with 17 at 30 mg/kg for 3 days.

Physicochemical Properties

M.Wt 313.405
Formula C17H23N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Month
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N-Dimethyl-1-(4-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)piperidine-4-carboxamide

References

1. Yuichi Kajita, et al. J Med Chem. 2022 Feb 15.

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