Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-CH24H inhibitor 17
CH24H inhibitor 17

Chemical Structure : CH24H inhibitor 17

CAS No.: 1613480-70-8

CH24H inhibitor 17

Catalog No.: PC-38337Not For Human Use, Lab Use Only.

CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.

Packing Price Stock Quantity
10 mg $228 In stock
25 mg $398 In stock
50 mg $588 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.
CH24H inhibitor 17 shows excellent selectivity for CYP3A4 as well as CYP2C8, CYP2C9, and CYP2D6 (IC50>10 uM).
CH24H inhibitor 17 reduces 24S-hydroxycholesterol levels in the mouse brain when oral administration treatment with 17 at 30 mg/kg for 3 days.

Physicochemical Properties

M.Wt 313.405
Formula C17H23N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Month
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N-Dimethyl-1-(4-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)piperidine-4-carboxamide

References

1. Yuichi Kajita, et al. J Med Chem. 2022 Feb 15.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: