Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CH24H inhibitor 17
CAS No.: 1613480-70-8
Catalog No.: PC-38337Not For Human Use, Lab Use Only.
CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.
CH24H inhibitor 17 shows excellent selectivity for CYP3A4 as well as CYP2C8, CYP2C9, and CYP2D6 (IC50>10 uM).
CH24H inhibitor 17 reduces 24S-hydroxycholesterol levels in the mouse brain when oral administration treatment with 17 at 30 mg/kg for 3 days.
| M.Wt | 313.405 | |
| Formula | C17H23N5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N,N-Dimethyl-1-(4-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)piperidine-4-carboxamide |
|
1. Yuichi Kajita, et al. J Med Chem. 2022 Feb 15.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
