CHD1Li 11 | CHD1L inhibitor | Probechem Biochemicals

Chemical Structure : CHD1Li 11

CHD1Li 11 (CHD1L inhibitor 11)

Catalog No.: PC-21580Not For Human Use, Lab Use Only.

CHD1Li 11 (CHD1L inhibitor 11) is a small molecule inhibitor of chromodomain helicase DNA-binding protein 1 like (CHD1L) with IC50 of 4.57 uM.

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Biological Activity

CHD1Li 11 (CHD1L inhibitor 11) is a small molecule inhibitor of chromodomain helicase DNA-binding protein 1 like (CHD1L) with IC50 of 4.57 uM.
CHD1Li 11 displays cytotoxicity with IC50 of 3.3 uM against SW620 tumor organoids.
CHD1Li 11 inhibits CSC stemness in CRC cells with IC50 of 0.34 uM.
CHD1Li 11 effectively reduces metastatic potential of aggressive mesenchymal tumor cells.

Physicochemical Properties

M.Wt	285.32
Formula	C16H16FN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(tert-butyl)-3-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

References

1. Sophia Clune, et al. Biomed Pharmacother. 2023 Dec 20:170:116037.

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CHD1Li 11 (CHD1L inhibitor 11)

Biological Activity

Physicochemical Properties

References

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