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CIB-3b

Chemical Structure : CIB-3b

CAS No.: 124811-87-6

CIB-3b (TRBP-Dicer inhihitor)

Catalog No.: PC-38904Not For Human Use, Lab Use Only.

CIB-3b is a small molecule inhibitor disrupting the TRBP-Dicer interaction, suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.

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Biological Activity

CIB-3b is a small molecule inhibitor disrupting the TRBP-Dicer interaction, suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.
CIB-3b directly binds to transactivation response (TAR) RNA-binding protein 2 (TRBP), altering the activity of Dicer and mature miRNA production.

Physicochemical Properties

M.Wt 261.277
Formula C14H15NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate

References

1. Ting Peng, et al. J. Med. Chem. 2022

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