CIB-Q22

Chemical Structure : CIB-Q22

Catalog No.: PC-27060Not For Human Use, Lab Use Only.

CIB-Q22 is a potent pyruvate carboxylase (PC) inhibitor with IC50 of 1.74 nM, suppresses HCC cell viability (IC50=25.18 nM).

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Biological Activity

CIB-Q22 is a potent pyruvate carboxylase (PC) inhibitor with IC50 of 1.74 nM, suppresses HCC cell viability (IC50=25.18 nM).
CIB-Q22 suppressed HCC proliferation and metastasis by inducing apoptosis and ferroptosis.
CIB-Q22 promoted mitochondrial oxidative stress and inhibited glycolysis, thereby sensitizing cells to glutamine deprivation.
CIB-Q22 exhibited comparable antitumor efficacy but improved safety compared to sorafenib.

Physicochemical Properties

M.Wt	335.38
Formula	C18H22FNO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-fluoro-6-methoxy-3-(3,4,5-trimethoxyphenethyl)aniline

References

1. Zeen Qiao, et al. J Med Chem. 2026 Jun 12. doi: 10.1021/acs.jmedchem.6c00075.

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CIB-Q22

Biological Activity

Physicochemical Properties

References

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