CID16020046 is a potent and selective GPR55 antagonist with IC50 of 0.15 uM.
CID16020046 significantly inhibits the LPI-induced ERK1/2 phosphorylation in HEK-GPR55 cells at 2.5 uM, concentration dependently inhibits LPI-induced activation of NFAT, NF-κB and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization.
CID16020046 reduces LPI-induced wound healing in primary human lung microvascular endothelial cells and reverses LPI-inhibited platelet aggregation.
