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Chemical Structure : CID16020046
CAS No.: 834903-43-4
Catalog No.: PC-45043Not For Human Use, Lab Use Only.
CID16020046 is a potent and selective GPR55 antagonist with IC50 of 0.15 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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CID16020046 is a potent and selective GPR55 antagonist with IC50 of 0.15 uM.
CID16020046 significantly inhibits the LPI-induced ERK1/2 phosphorylation in HEK-GPR55 cells at 2.5 uM, concentration dependently inhibits LPI-induced activation of NFAT, NF-κB and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization.
CID16020046 reduces LPI-induced wound healing in primary human lung microvascular endothelial cells and reverses LPI-inhibited platelet aggregation.
| M.Wt | 425.4361 | |
| Formula | C25H19N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]- |
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1. Kargl J, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.
2. Kargl J, et al. Br J Pharmacol. 2016 Jan;173(1):142-54.
3. Montecucco F, et al. Thromb Haemost. 2016 Oct 28;116(5):987-997.
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