Chemical Structure : CINS-1
CAS No.:
3143056-27-0
CINS-1
(CINS1)
Catalog No.: PC-28707Not For Human Use, Lab Use Only.
CINS-1 is a potent, specific RIO Kinase 1 (RIOK1) inhibitor with high binding affinity (ITC Kd=97 nM, AfRIOK1), binds to human RIOK1 with a Kd of 176 nM, exhibits antiproliferative activity against CRC cell lines HCT116 with IC50 of 7.81 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CINS-1 is a potent, specific RIO Kinase 1 (RIOK1) inhibitor with high binding affinity (ITC Kd=97 nM, AfRIOK1), binds to human RIOK1 with a Kd of 176 nM, exhibits antiproliferative activity against CRC cell lines HCT116 with IC50 of 7.81 uM.
CINS-1 exhibits poor inhibitory activity against VEGFR, EGFR, HER2, c-ABL, and AXL.
CINS-1 (10 uM) affects processing of 18S-E to 18S rRNA in CRC cells detected by FISH assay
CINS-1 activates P53-mediated nucleolar stress response in HCT116 cells.
CINS-1 (80 mg/kg, oral) significantly inhibited tumor growth subcutaneous xenograft model using human HCT116 cells.
Physicochemical Properties
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M.Wt
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354.41
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Formula
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C23H18N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N-([1,1'-biphenyl]-4-ylmethyl)-2-cyano-3-(4-hydroxyphenyl)acrylamide
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References
1. Jiang Y, et al. Acta Pharm Sin B. 2026 Oct;16(10):6831-6851.
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