Chemical Structure : CJB 090
CAS No.:
721882-80-0
CJB 090
(CJB090)
Catalog No.: PC-20864Not For Human Use, Lab Use Only.
CJB 090 (CJB090) is a selective partial agonist of dopamine D3 receptor with binding Ki of 0.6 nM, CJB 090 is 97-fold selective for D3 receptors over D2.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CJB 090 (CJB090) is a selective partial agonist of dopamine D3 receptor with binding Ki of 0.6 nM, CJB 090 is 97-fold selective for D3 receptors over D2.
CJB 090 significantly attenuates cocaine's discriminative stimulus effects in cocaine discrimination studies.
CJB 090 also significantly attenuates the partial cocaine-like stimulus effects of the preferential D3 receptor agonist PD 128907 but not the preferential D2 receptor agonist sumanirole.
CJB 090 does not attenuate either self-administration of cocaine or cocaine-induced reinstatement of extinguished drug-seeking at a dose that reduced responding maintained by food.
CJB 090 does not induce scratching or biting (species-typical effects of D2/3 receptor agonists) or catalepsy (typical effect of D2/3 receptor antagonists).
Physicochemical Properties
|
M.Wt
|
483.44
|
|
Formula
|
C26H28Cl2N4O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide
|
References
1. Achat-Mendes C, et al. Psychopharmacology (Berl). 2009 Sep;206(1):73-84.
2. Newman AH, et al. Bioorg Med Chem Lett. 2003;13:2179–2183.
Contact Us
sales@probechem.com
