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Chemical Structure : CJB 090
Catalog No.: PC-20864Not For Human Use, Lab Use Only.
CJB 090 (CJB090) is a selective partial agonist of dopamine D3 receptor with binding Ki of 0.6 nM, CJB 090 is 97-fold selective for D3 receptors over D2.
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CJB 090 (CJB090) is a selective partial agonist of dopamine D3 receptor with binding Ki of 0.6 nM, CJB 090 is 97-fold selective for D3 receptors over D2.
CJB 090 significantly attenuates cocaine's discriminative stimulus effects in cocaine discrimination studies.
CJB 090 also significantly attenuates the partial cocaine-like stimulus effects of the preferential D3 receptor agonist PD 128907 but not the preferential D2 receptor agonist sumanirole.
CJB 090 does not attenuate either self-administration of cocaine or cocaine-induced reinstatement of extinguished drug-seeking at a dose that reduced responding maintained by food.
CJB 090 does not induce scratching or biting (species-typical effects of D2/3 receptor agonists) or catalepsy (typical effect of D2/3 receptor antagonists).
| M.Wt | 483.44 | |
| Formula | C26H28Cl2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Achat-Mendes C, et al. Psychopharmacology (Berl). 2009 Sep;206(1):73-84.
2. Newman AH, et al. Bioorg Med Chem Lett. 2003;13:2179–2183.
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