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Chemical Structure : CK-0106023
Catalog No.: PC-70048Not For Human Use, Lab Use Only.
CK-0106023 (CK0106023) is a potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
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CK-0106023 (CK0106023) is a potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
CK-0106023 displays >200-fold selectivity over the mitotic kinesins CENP-E, MKLP1 and Kif1A.
CK-0106023 causes mitotic arrest and growth inhibition in several human tumor cell lines.
CK-0106023 exhibits antitumor activity in tumor-bearing mice.
| M.Wt | 595.96 | |
| Formula | C30H32BrClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sakowicz R, et al. Cancer Res. 2004 May 1;64(9):3276-80.
2. Zhang B, et al. Anal Biochem. 2005 Oct 15;345(2):326-35.
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