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CK-0106023

Chemical Structure : CK-0106023

CAS No.: 336115-72-1

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CK-0106023 (CK 0106023;CK0106023)

Catalog No.: PC-70048Not For Human Use, Lab Use Only.

CK-0106023 (CK0106023) is a potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CK-0106023 (CK0106023) is a potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
    CK-0106023 displays >200-fold selectivity over the mitotic kinesins CENP-E, MKLP1 and Kif1A.
    CK-0106023 causes mitotic arrest and growth inhibition in several human tumor cell lines.
    CK-0106023 exhibits antitumor activity in tumor-bearing mice.

    Physicochemical Properties

    M.Wt 595.96
    Formula C30H32BrClN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide

    References

    1. Sakowicz R, et al. Cancer Res. 2004 May 1;64(9):3276-80.

    2. Zhang B, et al. Anal Biochem. 2005 Oct 15;345(2):326-35.

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