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CK-2127107

Chemical Structure : CK-2127107

CAS No.: 1345410-31-2

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CK-2127107 (CK-107, Reldesemtiv)

Catalog No.: PC-60222Not For Human Use, Lab Use Only.

CK-2127107 (CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CK-2127107 (CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
CK-2127107 (CK-107, Reldesemtiv) has no effect on slow skeletal or cardiac myofibrils.
CK-2127107 (CK-107, Reldesemtiv) significantly improves rotarod performance in exercise-intolerant LAD-HF rats.

Physicochemical Properties

M.Wt 384.391
Formula C19H18F2N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide

References

1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68.

2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.

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