Chemical Structure : CLK1 inhibitor 25
CAS No.:
2123491-32-5
CLK1 inhibitor 25
Catalog No.: PC-21433Not For Human Use, Lab Use Only.
CLK1 inhibitor 25 is a potent and selective inhibitor of cdc2-like kinase 1 (CLK1) with IC50 of 2 nM, 69-fold selective over DYRK1A.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CLK1 inhibitor 25 is a potent and selective inhibitor of cdc2-like kinase 1 (CLK1) with IC50 of 2 nM, 69-fold selective over DYRK1A.
CLK1 inhibitor 25 also potently inhibits CLK2 (IC50: 31 nM) and CLK4 (IC50: 8 nM).
CLK1 inhibitor 25 displays at least 110-fold selectivity toward CLK1 over 351 of the 357 kinases tested (98.32%), does not show obvious activity against 292 kinases (IC50>10 μM).
CLK1 inhibitor 25 (10 uM) alters the location and redistribution of SR proteins in BNL CL.2 cells.
CLK1 inhibitor 25 induces autophagy in in vitro assays and displays significant hepatoprotective effects in the acetaminophen (APAP)-induced liver injury mouse model.
Physicochemical Properties
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M.Wt
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409.42
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Formula
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C24H16FN5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-5-(1-(1-(4-fluorophenyl)ethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)benzo[d]oxazole
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References
1. Sun QZ, et al. J Med Chem. 2017 Jul 27;60(14):6337-6352.
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