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Chemical Structure : CLK inhibitor 2
Catalog No.: PC-61026Not For Human Use, Lab Use Only.
CLK inhibitor 2 is a potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively.
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CLK inhibitor 2 is a potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively.
CLK inhibitor 2 moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
CLK inhibitor 2 inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.
| M.Wt | 360.421 | |
| Formula | C20H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929.
2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.
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