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CLK inhibitor 2

Chemical Structure : CLK inhibitor 2

CAS No.: 1005776-20-4

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CLK inhibitor 2

Catalog No.: PC-61026Not For Human Use, Lab Use Only.

CLK inhibitor 2 is a potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CLK inhibitor 2 is a potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively.
    CLK inhibitor 2 moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
    CLK inhibitor 2 inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.

    Physicochemical Properties

    M.Wt 360.421
    Formula C20H20N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl)-6-(tert-butyl)nicotinamide

    References

    1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929.

    2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.

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