CLM296 | ALDH1A3 inhibitor | Probechem Biochemicals

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Chemical Structure : CLM296

CLM296 (CLM-296)

Catalog No.: PC-26285Not For Human Use, Lab Use Only.

CLM296 (CLM-296) is a highly potent, selective inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with IC50 of 2 nM for inhibition of ALDH1A3 in TNBC cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CLM296 (CLM-296) is a highly potent, selective inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with IC50 of 2 nM for inhibition of ALDH1A3 in TNBC cells.
CLM296 inhibits ALDH1A3-mediated Aldefluor fluorescence and is specific for ALDH1A3.
CLM296 (100 nM) specifically blocks ALDH1A3-mediated gene expression changes in TNBC cells.
CLM296 (0.4 and 4 mg/kg, i.p.) in specifically impedes ALDH1A3-mediated tumor growth and metastasis in MDA-MB-231 ALDH1A3 OE tumor-bearing mice.

Physicochemical Properties

M.Wt	430.51
Formula	C29H22N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1'-((2-phenylimidazo[1,2-a]pyridine-6,8-diyl)bis(4,1-phenylene))bis(ethan-1-one)

References

1. MacLean MR, et al. iScience. 2026 Jan 31;29(3):114863.

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CLM296 (CLM-296)

Biological Activity

Physicochemical Properties

References

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