CMAP compound 5 | Hedgehog inhibitor, GPR39 agonist

Chemical Structure : CMAP compound 5

CMAP compound 5 (CMAP5)

Catalog No.: PC-23367Not For Human Use, Lab Use Only.

CMAP compound 5 (CMAP5) is a potent, small molecule Hedgehog pathway inhibitor with EC50 of 0.02 uM, blocks pathway signaling in a Smo-independent manner, activates GPR39.

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Biological Activity

CMAP compound 5 (CMAP5) is a potent, small molecule Hedgehog pathway inhibitor with EC50 of 0.02 uM, blocks pathway signaling in a Smo-independent manner, activates GPR39.

Physicochemical Properties

M.Wt	491.61
Formula	C25H29N7O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Cyano-N-[[trans-4-[[[4-(methylamino)-6-(2-pyridinyl)-2-pyrimidinyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide

References

1. Bassilana F, et al. Nat Chem Biol. 2014 May;10(5):343-9.

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CMAP compound 5 (CMAP5)

Biological Activity

Physicochemical Properties

References

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