CMM-98 | OGG1 activator | Probechem Biochemicals

Chemical Structure : CMM-98

CMM-98 (CMM98)

Catalog No.: PC-28421Not For Human Use, Lab Use Only.

CMM-98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively.

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Biological Activity

CMM-98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively.
CMM-98 installs a robust AP-site processing function in the DNA glycosylase OGG1 by binding the active site.
CMM-98 effectively rewires the enzyme's catalytic outcome under oxidative stress, boosting AP site turnover by 57‐fold.
CMM-98 reduces oxidative DNA damage burden, promotes the resolution of oxidative DNA lesions, and ameliorates hepatocyte injury.
CMM-98 exhibits selectivity against representative DNA glycosylases and a wider kinase panel.

Physicochemical Properties

M.Wt	320.40
Formula	C18H20N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-N4-phenyl-N2-(2-(pyridin-3-ylamino)ethyl)pyrimidine-2,4-diamine

References

1. Zhao Z, et al. Adv Sci (Weinh). 2026 Sep 27:e77956.

CMM-98 (CMM98)

Biological Activity

Physicochemical Properties

References

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