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CMPD167

Chemical Structure : CMPD167

CAS No.: 313994-79-5

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CMPD167 (CMPD 167, MRK-1)

Catalog No.: PC-61964Not For Human Use, Lab Use Only.

CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).

    Physicochemical Properties

    M.Wt 574.785
    Formula C35H47FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1R,3S,4S)-3-((4-(3-benzyl-1-ethyl-1H-pyrazol-5-yl)piperidin-1-yl)methyl)-4-(3-fluorophenyl)cyclopentyl)-N-methyl-D-valine

    References

    1. Veazey RS, et al. Nature. 2005 Nov 3;438(7064):99-102.

    2. Veazey RS, et al. Nat Med. 2005 Dec;11(12):1293-4.

    3. Ketas TJ, et al. Virology. 2007 Aug 1;364(2):431-40.

    4. Malcolm RK, et al. Antimicrob Agents Chemother. 2012 May;56(5):2251-8.

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