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Chemical Structure : CN210
Catalog No.: PC-21303Not For Human Use, Lab Use Only.
CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay.
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CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay.
CN210 is highly effective in inhibiting tumor growth in a Kasumi-1 xenograft mouse model.
CN210 also demonstrates significant improvement of arthritis severity in a collagen-induced arthritis (CIA) mouse model.
CN210 is a potential drug candidate with a unique mechanism of action to treat NSAID-induced ileitis and IBD.
| M.Wt | 524.63 | |
| Formula | C30H32N6O3: | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takehisa Noguchi, et al. Drug Dev Res. 2021 Dec;82(8):1235-1246.
2. Yang SM, et al. Bioorganic & Medicinal Chemistry Letters, 29, 1220–1226.
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