CN210 | BET bromodomain inhibitor | Probechem Biochemicals

Chemical Structure : CN210

CN210 (CN 210)

Catalog No.: PC-21303Not For Human Use, Lab Use Only.

CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay.

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Biological Activity

CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay.
CN210 is highly effective in inhibiting tumor growth in a Kasumi-1 xenograft mouse model.
CN210 also demonstrates significant improvement of arthritis severity in a collagen-induced arthritis (CIA) mouse model.
CN210 is a potential drug candidate with a unique mechanism of action to treat NSAID-induced ileitis and IBD.

Physicochemical Properties

M.Wt	524.63
Formula	C30H32N6O3:
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-(6-(3,5-dimethylisoxazol-4-yl)-4-(3-phenylmorpholino)quinazolin-2-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

References

1. Takehisa Noguchi, et al. Drug Dev Res. 2021 Dec;82(8):1235-1246.

2. Yang SM, et al. Bioorganic & Medicinal Chemistry Letters, 29, 1220–1226.

CN210 (CN 210)

Biological Activity

Physicochemical Properties

References

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