Chemical Structure : CNBCA
CAS No.:
CNBCA
Catalog No.: PC-20975Not For Human Use, Lab Use Only.
CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes.
CNBCA shows good selectivity (>25-fold) over SHP1 and PTP1B in the phosphatase assays.
CNBCA binds to endogenous full-length SHP2 under cellular contexts, inhibits FL-SHP2 with IC50 of 0.615 uM in PTPase assays.
CNBCA effectively downregulates SHP2 mediated signaling in breast cancer (BC) cells, inhibits SHP2 mediated Akt and ERK1/2 activation in the BT474 and MDA-MB468 cells with IC50 of 1 uM.
CNBCA (500 nM) is effective in suppressing the cancer stem cell properties of BC cells.
Physicochemical Properties
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M.Wt
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426.55
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Formula
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C26H34O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=CC=C(C2=CC=C(OCCCCCCCCC)C(CCCC(O)=O)=C2)C=C1)O
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References
1. Dhanaji M. Lade, et al. ACS Bio Med Chem Au 2023
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