Chemical Structure : CNS-11
CAS No.:
445218-34-8
CNS-11
Catalog No.: PC-49766Not For Human Use, Lab Use Only.
CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.
CNS-11 is more predictive of oral bioavailability and central nervous system penetration compared to EGCG.
CNS-11 (10 uM) inhibits intracellular seeding in alpha-synuclein biosensor cells and mitigation of alpha-synuclein cytotoxicity.
CNS-11 disaggregates MSA patient brain-derived alpha-synuclein fibrils in vitro, reduces alpha-synuclein aggregates in C. elegans, also could penetrate brain tissue in mice.
Physicochemical Properties
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M.Wt
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395.46
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Formula
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C25H21N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-mesityl-2-(3-oxoindeno[1,2,3-de]phthalazin-2(3H)-yl)acetamide
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References
1. Murray KA, et al. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120.
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