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Chemical Structure : CNS-11
Catalog No.: PC-49766Not For Human Use, Lab Use Only.
CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.
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CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.
CNS-11 is more predictive of oral bioavailability and central nervous system penetration compared to EGCG.
CNS-11 (10 uM) inhibits intracellular seeding in alpha-synuclein biosensor cells and mitigation of alpha-synuclein cytotoxicity.
CNS-11 disaggregates MSA patient brain-derived alpha-synuclein fibrils in vitro, reduces alpha-synuclein aggregates in C. elegans, also could penetrate brain tissue in mice.
| M.Wt | 395.46 | |
| Formula | C25H21N3O2 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Murray KA, et al. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120.
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