Catalog No.: PC-36018Not For Human Use, Lab Use Only.
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.
COH-SR4 prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models.
COH-SR4 exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC).
COH-SR4 inhibits vemurafenib-resistant melanoma in vivo.
Physicochemical Properties
M.Wt
350.02
Formula
C13H8Cl4N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,3-bis(3,5-dichlorophenyl)urea
References
1. Singhal SS, et al. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27.
2. Figarola JL, et al. Oncotarget. 2018 Dec 11;9(97):36945-36965.
3. Singhal SS, et al. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72.
4. Figarola JL, et al. PLoS One. 2013 Dec 20;8(12):e83801.
