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Chemical Structure : COH-SR4
CAS No.: 73439-19-7
Catalog No.: PC-36018Not For Human Use, Lab Use Only.
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $58 | In stock | |
| 100 mg | $98 | In stock | |
| 250 mg | $148 | In stock | |
| 1 g | Get quote |
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COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.
COH-SR4 prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models.
COH-SR4 exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC).
COH-SR4 inhibits vemurafenib-resistant melanoma in vivo.
| M.Wt | 350.02 | |
| Formula | C13H8Cl4N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,3-bis(3,5-dichlorophenyl)urea |
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1. Singhal SS, et al. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27.
2. Figarola JL, et al. Oncotarget. 2018 Dec 11;9(97):36945-36965.
3. Singhal SS, et al. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72.
4. Figarola JL, et al. PLoS One. 2013 Dec 20;8(12):e83801.
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