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COTI-2

Chemical Structure : COTI-2

CAS No.: 1039455-84-9

COTI-2 (COTI2)

Catalog No.: PC-61494Not For Human Use, Lab Use Only.

COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway.
COTI-2 induces apoptosis in a wide variety of human tumor cells in culture (IC50s<40 nM), inhibits the proliferation of colorectal cancer cell lines more effectively than cetuximab and erlotinib.
COTI-2 shows superior activity against tumor, and is safe and well-tolerated in vivo.

Physicochemical Properties

M.Wt 366.5
Formula C19H22N6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(2-pyridinyl)-2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide-1-piperazinecarbothioic acid

References

1. Salim KY, et al. Oncotarget. 2016 Jul 5;7(27):41363-41379.

2. Duffy MJ, et al. Eur J Cancer. 2017 Jul 27;83:258-265.

3. Heffeter P, et al. Antioxid Redox Signal. 2018 Jan 15. doi: 10.1089/ars.2017.7487.

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