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CP-31398 dihydrochloride

Chemical Structure : CP-31398 dihydrochloride

CAS No.: 1217195-61-3

CP-31398 dihydrochloride (CP31398 dihydrochloride)

Catalog No.: PC-62082Not For Human Use, Lab Use Only.

CP-31398 (CP31398) dihydrochloride is a small molecule p53 reactivator that protects p53 from thermal denaturation, not only reactivates mutant p53 but also induces stabilization of wild type p53.

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Biological Activity

CP-31398 (CP31398) dihydrochloride is a small molecule p53 reactivator that protects p53 from thermal denaturation, not only reactivates mutant p53 but also induces stabilization of wild type p53.
CP-31398 shows anti-tumor activity in vivo in a transgenic UPII-SV40T mouse model of bladder transitional cell carcinoma.

Physicochemical Properties

M.Wt 435.39
Formula C22H26N4O.2HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride

References

1. Foster BA, et al. Science. 1999 Dec 24;286(5449):2507-10.

2. Madka V, et al. Neoplasia. 2013 Aug;15(8):966-74.

3. Wang W, et al. Mol Cell Biol. 2003 Mar;23(6):2171-81.

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