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CP-9

Chemical Structure : CP-9

CAS No.: 505056-50-8

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CP-9 (Hsp90α/p23 inhibitor CP-9)

Catalog No.: PC-70362Not For Human Use, Lab Use Only.

CP-9 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM, 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CP-9 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM, 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM).
    CP-9 treatment leads to various levels of degradation of pAkt/total Akt and Raf-1 in cancer cell lines, but has no effect on the expression of the Hsp90 client proteins in normal mouse embryonic fibroblasts (MEFs).
    CP-9 inhibits cell proliferation, glucose metabolism, and mammalian thymidine kinase activities in multiple cancer cell lines.

    Physicochemical Properties

    M.Wt 400.394
    Formula C15H11F3N4O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-methylisoxazol-3-yl)-2-[4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio]acetamide

    References

    1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85.

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