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Chemical Structure : CP-9
Catalog No.: PC-70362Not For Human Use, Lab Use Only.
A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM.
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A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM; 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM); leads to various levels of degradation of pAkt/total Akt and Raf-1 in cancer cell lines, but has no effect on the expression of the Hsp90 client proteins in normal mouse embryonic fibroblasts (MEFs); inhibits cell proliferation, glucose metabolism, and mammalian thymidine kinase activities in multiple cancer cell lines.
| M.Wt | 400.394 | |
| Formula | C15H11F3N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85.
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