CP681301 | CDK5 inhibitor | Probechem Biochemicals

Chemical Structure : CP681301

CAS No.: 865317-32-4

CP681301 (CP 681301)

Catalog No.: PC-21703Not For Human Use, Lab Use Only.

CP681301 is a potent, highly specific CDK5 inhibitor, completely inhibits both CDK5-P35 and CDK5-P25 at 1 uM.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$218	In stock
25 mg	$368	In stock
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Biological Activity

CP681301 is a potent, highly specific CDK5 inhibitor, completely inhibits both CDK5-P35 and CDK5-P25 at 1 uM.
CP681301 is more specific to CDK5 than its closest relative CDK2.
CP681301 (1 uM) reduces stem cell markers CD133, OLIG2, and SOX2 and the cell proliferation marker Ki67 in GBM GSC cultures.
CP681301 reduces CDK5 activation, stem cell marker expression, and cell proliferation in mouse xenografts ex vivo.

Physicochemical Properties

M.Wt	298.39
Formula	C17H22N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-Cyclobutyl-1H-pyrazol-3-yl)-4-(dimethylamino)benzeneacetamide

References

1. Subhas Mukherjee, et al. Cell Rep. 2018 May 8;23(6):1651-1664.

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CP681301 (CP 681301)

Biological Activity

Physicochemical Properties

References

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