CPI-1328 | EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : CPI-1328

CPI-1328 (CPI 1328)

Catalog No.: PC-20857Not For Human Use, Lab Use Only.

CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM).

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Biological Activity

CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM).
CPI-1328 exhibited dose-dependent reduction in H3K27me3 levels with 10 mg/kg QD CPI-1328 causing a 43% reduction in H3K27me3 levels and 25 mg/kg QD CPI-1328 causing an 89% reduction in H3K27me3 levels in mice.

Physicochemical Properties

M.Wt	546.12
Formula	C28H36ClN3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	CC1=C2C(CCN(CC3=C(SC)C=C(C)NC3=O)C2=O)=C(Cl)C4=C1O[C@](C5CC[C@H](N(C)C)CC5)(C)O4

References

1. Jacob I Stuckey, et al. J Biol Chem. 2021 Jan-Jun;296:100349.

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CPI-1328 (CPI 1328)

Biological Activity

Physicochemical Properties

References

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