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Chemical Structure : CPI-1328
Catalog No.: PC-20857Not For Human Use, Lab Use Only.
CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM).
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CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM).
CPI-1328 exhibited dose-dependent reduction in H3K27me3 levels with 10 mg/kg QD CPI-1328 causing a 43% reduction in H3K27me3 levels and 25 mg/kg QD CPI-1328 causing an 89% reduction in H3K27me3 levels in mice.
| M.Wt | 546.12 | |
| Formula | C28H36ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jacob I Stuckey, et al. J Biol Chem. 2021 Jan-Jun;296:100349.
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