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Chemical Structure : CPI203
CAS No.: 1446144-04-2
Catalog No.: PC-62511Not For Human Use, Lab Use Only.
CPI 203 (TEN 010, JQ-2, RG-6146, RO6870810) is a primary amide analog of (+)-JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $285 | In stock | |
| 50 mg | $485 | In stock | |
| 100 mg | $745 | In stock | |
| 1 g | Get quote |
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CPI 203 (TEN 010, JQ-2, RG-6146, RO6870810) is a primary amide analog of (+)-JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM.
CPI 203 synergizes the antitumor activity of lenalidomide in bortezomib-resistant mantle cell lymphoma.
CPI 203 also enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors, overcomes resistance to ABT-199 (Venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma.
| M.Wt | 399.897 | |
| Formula | C19H18ClN5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
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1. Moros A, et al. Leukemia. 2014 Oct;28(10):2049-59.
2. Wong C, et al. Cell Death Dis. 2014 Oct 9;5:e1450.
3. Siegel MB, et al. Oncotarget. 2015 Aug 7;6(22):18921-32.
4. Esteve-Arenys A, et al. Oncogene. 2018 Jan 22. doi: 10.1038/s41388-017-0111-1.
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