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CPI644

Chemical Structure : CPI644

CAS No.: 1904647-34-2

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CPI644 (CPI 644, CPI-644)

Catalog No.: PC-60857Not For Human Use, Lab Use Only.

CPI644 (CPI-644) is a potent, selective, cell-active CREBBP/EP300 bromodomain inhibitor with IC50 of 0.18 uM for CREBBP.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CPI644 (CPI-644) is a potent, selective, cell-active CREBBP/EP300 bromodomain inhibitor with IC50 of 0.18 uM for CREBBP.
    CPI644 displays little to no (>400-fold selectivity) activity for BRD9, BRD4, BRPF1, TRIM24, BRG1 and BACF (IC50>10 uM).
    CPI644 inhibits CBP bromodomain binding in a dose-dependent manner with cellular EC50 of 0.53 uM,.
    CPI644 reduces FOXP3 expression both at protein and transcript levels with no appreciable effect on cell viability.

    Physicochemical Properties

    M.Wt 357.428
    Formula C18H19N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R,E)-2-(2-(4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-6-yl)vinyl)benzenesulfonamide

    References

    1. Ghosh S, et al. J Biol Chem. 2016 Jun 17;291(25):13014-27.

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