CPI703 |CAS:1904649-00-8 Probechem Biochemicals

Chemical Structure : CPI703

CPI703 (CPI-703;CPI 703)

Catalog No.: PC-60856Not For Human Use, Lab Use Only.

CPI-703 (CPI703) potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP.

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Biological Activity

CPI-703 (CPI703) potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP.
CPI-703 displays little to no (>200-fold selectivity) activity for BRD9, BRD4, BRPF1, TRIM24, BRG1 and BACF (IC50>10 uM).
CPI-703 inhibits CBP bromodomain binding in a dose-dependent manner with cellular EC50 of 2.1 uM, reduces Treg differentiation and exhibits FOXP3 inhibition with IC50 of 1.5 uM.
CPI-703 significantly affects TH17 differentiation, suppresses TH17 cytokines, IL-17A, IL-17F, and IL-21 with no effect on TNFα production or cell viability.

Physicochemical Properties

M.Wt	298.39
Formula	C17H22N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-(1-(tert-butyl)-1H-pyrazol-4-yl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one

References

1. Ghosh S, et al. J Biol Chem. 2016 Jun 17;291(25):13014-27.

CPI703 (CPI-703;CPI 703)

Biological Activity

Physicochemical Properties

References

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