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Chemical Structure : CPL409116
Catalog No.: PC-49651Not For Human Use, Lab Use Only.
CPL409116 (CPL 409116) is a potent, competitive, dual JAK and ROCK inhibitor with IC50 of 0.95/5.36//0.87/110.6/106.7 nM for JAK1/JAK2/JAK3/ROCK1/ROCK2, respectively.
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CPL409116 (CPL 409116) is a potent, competitive, dual JAK and ROCK inhibitor with IC50 of 0.95/5.36//0.87/110.6/106.7 nM for JAK1/JAK2/JAK3/ROCK1/ROCK2, respectively.
CPL409116 is a selective JAK/ROCK inhibitor, and is more specific towards JAK1 and JAK3 than JAK2.
CPL409116 blocked phosphorylation of JAK and ROCK kinase substrates STAT and MYPT, respectively.
CPL409116 efficiently blocked expression of a broad range of cytokines, efficiently blocked CD4 T cell proliferation with IC50 of 59 nM.
CPL409116 (40 mg/kg QD) improved survival and clinical parameters of murine lupus, ameliorated kidney nephropathy.
| M.Wt | 498.55 | |
| Formula | C25H26N10O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dulak-Lis M, et al. J Pharmacol Sci. 2021 Apr;145(4):340-348.
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