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CPN-351

Chemical Structure : CPN-351

CAS No.: 3057171-63-5

CPN-351 (CPN351)

Catalog No.: PC-26901Not For Human Use, Lab Use Only.

CPN-351 is a potent, selective pentapeptide antagonist of Neuromedin U Receptor 1 (NMUR1) with pA2 and KB values of 7.35 and 45 nM, respectively, selective over NMUR2 with 6.38 and 421 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CPN-351 is a potent, selective pentapeptide antagonist of Neuromedin U Receptor 1 (NMUR1) with pA2 and KB values of 7.35 and 45 nM, respectively, selective over NMUR2 with 6.38 and 421 nM, respectively.

Physicochemical Properties

M.Wt 912.13
Formula C45H61N13O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(((S)-2-((S)-3-(1H-indol-3-yl)-2-(N-methyl-2-(thiophen-2-yl)acetamido)propanamido)-2-methyl-3-phenylpropanoyl)-L-arginyl)-N-((S)-1-amino-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide

References

1. Kentaro Takayama, et al. ACS Med Chem Lett. 2024 May 24;15(6):885-891.

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