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CPP-115

Chemical Structure : CPP-115

CAS No.: 640897-20-7

CPP-115 (CPP115)

Catalog No.: PC-62759Not For Human Use, Lab Use Only.

CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities.
    CPP-115 displays superior enzyme inactivation properties compared to vigabatrin, decreases spasms in the multiple-hit rat model of infantile spasms.
    CPP-115 deonstrates high therapeutic potential for the treatment of cocaine addiction and for a variety of epilepsies.

    Physicochemical Properties

    M.Wt 177.151
    Formula C7H9F2NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (1S,3S)-3-amino-4-(difluoromethylidene)cyclopentane-1-carboxylic acid

    References

    1. Pan Y, et al. J Med Chem. 2012 Jan 12;55(1):357-66.

    2. Briggs SW, et al. Epilepsia. 2014 Jan;55(1):94-102.

    3. Lee H, et al. J Am Chem Soc. 2015 Feb 25;137(7):2628-40.

    4. Prescot AP, et al. Neuropsychopharmacology. 2018 Feb;43(3):646-654.

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