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Chemical Structure : CPP-115
Catalog No.: PC-62759Not For Human Use, Lab Use Only.
CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities.
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CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities; displays superior enzyme inactivation properties compared to vigabatrin, decreases spasms in the multiple-hit rat model of infantile spasms, deonstrates high therapeutic potential for the treatment of cocaine addiction and for a variety of epilepsies.
Epilepsy
Phase 2 Clinical
| M.Wt | 177.151 | |
| Formula | C7H9F2NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pan Y, et al. J Med Chem. 2012 Jan 12;55(1):357-66.
2. Briggs SW, et al. Epilepsia. 2014 Jan;55(1):94-102.
3. Lee H, et al. J Am Chem Soc. 2015 Feb 25;137(7):2628-40.
4. Prescot AP, et al. Neuropsychopharmacology. 2018 Feb;43(3):646-654.
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