Chemical Structure : CQ3196
CAS No.:
CQ3196
(CQ-3196)
Catalog No.: PC-25339Not For Human Use, Lab Use Only.
CQ3196 is a potent and orally bioavailable RIO kinase 2 (RIOK2) inhibitor with binding Kd of 14 nM, suppresses RIOK2 ATPase activity in vitro with IC50 of 72 nM in an ADP-Glo kinase assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CQ3196 is a potent and orally bioavailable RIO kinase 2 (RIOK2) inhibitor with binding Kd of 14 nM, suppresses RIOK2 ATPase activity in vitro with IC50 of 72 nM in an ADP-Glo kinase assays.
CQ3196 displays potent inhibitory effects on the proliferation of gastric cancer cells, with IC50 values of 0.46 μM in HGC-27 and 0.73 μM in AGS, as well as chronic myelogenous leukemia cells (IC50 = 0.90 μM in K562).
CQ3196 induces cell apoptosis at indicated concentrations in HGC-27 and AGS cells, modulates ribosome function and protein synthesis.
CQ3196 significantly decreases the phosphorylation of AKT in HGC-27 cells from 300 nM.
CQ3196 (25 mg/kg or 50 mg/kg), oral) inhibits tumor growth in the HGC-27 Tumor xenografted model.
Physicochemical Properties
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M.Wt
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577.61
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Formula
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C30H30F3N7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-(4-Methoxy-8-(6-methoxypyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-2-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-4-amine
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References
1. Haowen Ma, et al. J Med Chem. 2025 Aug 14. doi: 10.1021/acs.jmedchem.5c01424.
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